GEWALD REACTION PDF

Associate Editor: D. Chen Beilstein J. The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. Keywords: design of experiment DOE ; 1,4-dithiane-2,5-diol; Gewald reaction; thiazole; thiophene. Several protocols have already been described for the synthesis of substituted thiazoles and benzothiazoles []. Consequently, expanding the scope of thiazole synthesis by developing new methodologies remains an active area of research.

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We'd like to understand how you use our websites in order to improve them. Register your interest. The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component G-3CR yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry.

Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products. This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. Neuropsychopharmacology 83— Eli Lilly and Company Annual Report.

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Reprints and Permissions. Huang, Y. The Gewald multicomponent reaction. Mol Divers 15, 3—33 Download citation. Received : 12 August Accepted : 03 February Published : 27 February Issue Date : February Search SpringerLink Search. Abstract The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component G-3CR yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry.

Immediate online access to all issues from Subscription will auto renew annually. You can also search for this author in PubMed Google Scholar. View author publications. Rights and permissions Reprints and Permissions. About this article Cite this article Huang, Y.

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Gewald reaction

We'd like to understand how you use our websites in order to improve them. Register your interest. The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component G-3CR yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products. This is a preview of subscription content, log in to check access.

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